May 4, 1965 marked the establishment of the College of Arts and Sciences (then the School of Arts and Sciences) under Republic Act no. 4189, which converted the Iloilo Normal School into West Visayas State College. The first Dean of the College of Arts and Sciences was Dr. Ma. Celia R. Palma.
The Liberal Arts curriculum was opened in 1970, offering courses leading to majors in English and Social Sciences. The original Liberal Arts offered courses leading to major in English and minor in Social Science. Course offerings were later expanded to prepare students for teaching in secondary schools and in college with majors in English, Home Economics, Physical Education, and Filipino. The courses leading to teaching were gradually phased out, however.
In 1975, the pre-medical A.B. major in Science curriculum was opened to prepare students for entrance to medical school. Resolution No. 9, series 1981, passed by the Board of Trustees on February 27, 1981, authorized the revision of the curriculum to include courses leading to a Bachelor of Science degree with majors in Biological Science, Physical Science and Mass Communications.On January 27, 1986, the West Visayas State College was converted to West Visayas State University with the passage of Presidential Decree 2019. In 1988, Dr. Ma. Celia R. Palma retired, leaving the deanship of the College to Dr. Alberto J. Trinidad. During his term, the Board of Regents (BOR) authorized the offering of BS in Mass Communications (with majors in Broadcasting, Journalism, and Development Communication) and AB Political Science on April 8, 1991 under BOR Resolution no. 35, series of 1991. After three years, the Department of Mass Communications was converted into an independent degree-granting academic unit and was separated from the College.